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Furthermore, the concentration of several metabolites was higher in the 4+1 group compared to the other two treated and control groups except for L-cysteine, D-glucose, L-glutamic acid, and pyruvate, which were lower ( Figure 1B and Figure 2 )

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Moreover, reduced gliotoxin can also initiate the generation of excessive ROS and the disruption of membrane potential, thus further promoting apoptosis in CRCs [86]